Technology

Redefining the design, distribution, and delivery of genetic medicines.

We are building a genetic infrastructure that combines advanced plasmid design, digital security, and clean DNA formats to accelerate development, improve safety, and lower the cost of genetic medicines.

TrueVectors™

TrueVectors aren’t repurposed legacy plasmids — they’re generated by a rule-based computational system that applies formal design principles to DNA.

  • Built by a generative design engine: Every TrueVector is produced by software that encodes design rules, not intuition. That means fewer errors, consistent quality, and easy reproducibility.
  • Clean, modular architecture: Organized into functional blocks you can swap, reuse, or optimize — without redesigning from scratch.
  • High-throughput ready: Whether you need one plasmid or a library of 100 variants, TrueVectors scale with your experiments.
  • Reliable and transparent: Complete annotations and traceability help you focus on biology, not troubleshooting.

    TrueVectors give you a clean slate — designed by algorithms, built for scientists.

GSIN™

The GenoCAD Standard Identification Number (GSIN) applies cybersecurity principles to molecular biology. Inspired by software licensing technologies, GSIN embeds a unique digital certificate directly into each iVector’s DNA.

  • Traceable by design: Each plasmid carries a built-in serial number that links it to its developer, user, and supporting documentation.
  • Tamper-resistant: GSIN enables recovery of a plasmid’s identity and critical data from raw sequencing data without prior knowledge, even in the presence of mutations or sequencing errors.
  • Secures plasmid exchange: GSIN protects against mix-ups, misidentification, and data loss when constructs move between collaborators, vendors, and platforms.
  • Strengthens the supply chain: With verifiable plasmid provenance, GSIN reduces uncertainty in sourcing, QC, and long-term project management.
    GSIN brings digital trust to biotechnology — ensuring that your DNA can speak for itself.

CorePrep™

CorePrep is GenoCAD's proprietary method for producing supercoiled circular DNA molecules without any bacterial backbone sequences — no origins of replication, no antibiotic resistance markers.

Why it matters:

  • Removing unnecessary sequences reduces molecular weight, improving transfection efficiency in mammalian cells.
  • CorePrep DNA avoids features regulatory agencies often flag, such as antibiotic resistance genes or bacterial elements.
  • Deliver genes that can’t be propagated in E. coli — no cloning bottlenecks.
  • CorePrep DNA can serve as a clean, high-performance template for in vitro transcription and translation systems.

CorePrep delivers exactly what your system needs — and nothing it doesn’t.

Compliance and Biosecurity

We comply with all relevant U.S. federal policies related to biosecurity, synthetic DNA screening, and export control. Every order is screened using Aclid, a state-of-the-art platform for identifying sequences that may pose a potential biological hazard.

As part of our commitment to responsible innovation, we also practice customer due diligence. If a sequence or order raises concerns, we may request additional information about:

  • intended use of the DNA
  • nature of the project
  • identity of the client

These measures help ensure that our technology is used safely and in alignment with public health and security standards.

Learn more about Aclid ›

Backed by Research. Built with Purpose.

GenoCAD’s technologies are grounded in over a decade of peer-reviewed research and federally funded innovation.

Supported by Major U.S. Funding Agencies

Our work has been funded by the National Science Foundation and the National Institutes of Health:

  • NIH R01GM147816: Development
    of a technology to certify engineered DNA molecules
  • NSF 1241328: INSPIRE: Modeling and optimization of DNA manufacturing processes
  • NSF 0850100: GenoCAD: A Computer Assisted Design Environment for Synthetic Biology

Published in High-Impact Journals

Our innovations have been validated through publications cited thousands of times in the scientific literature.