Technology
Redefining the design, distribution, and delivery of genetic medicines.
We are building a genetic infrastructure that combines advanced plasmid design, digital security, and clean DNA formats to accelerate development, improve safety, and lower the cost of genetic medicines.

TrueVectors™
TrueVectors aren’t repurposed legacy plasmids — they’re generated by a rule-based computational system that applies formal design principles to DNA.
- Built by a generative design engine: Every TrueVector is produced by software that encodes design rules, not intuition. That means fewer errors, consistent quality, and easy reproducibility.
- Clean, modular architecture: Organized into functional blocks you can swap, reuse, or optimize — without redesigning from scratch.
- High-throughput ready: Whether you need one plasmid or a library of 100 variants, TrueVectors scale with your experiments.
- Reliable and transparent: Complete annotations and traceability help you focus on biology, not troubleshooting.
TrueVectors give you a clean slate — designed by algorithms, built for scientists.

GSIN™
The GenoCAD Standard Identification Number (GSIN) applies cybersecurity principles to molecular biology. Inspired by software licensing technologies, GSIN embeds a unique digital certificate directly into each iVector’s DNA.
- Traceable by design: Each plasmid carries a built-in serial number that links it to its developer, user, and supporting documentation.
- Tamper-resistant: GSIN enables recovery of a plasmid’s identity and critical data from raw sequencing data without prior knowledge, even in the presence of mutations or sequencing errors.
- Secures plasmid exchange: GSIN protects against mix-ups, misidentification, and data loss when constructs move between collaborators, vendors, and platforms.
- Strengthens the supply chain: With verifiable plasmid provenance, GSIN reduces uncertainty in sourcing, QC, and long-term project management.
GSIN brings digital trust to biotechnology — ensuring that your DNA can speak for itself.

CorePrep™
CorePrep is GenoCAD's proprietary method for producing supercoiled circular DNA molecules without any bacterial backbone sequences — no origins of replication, no antibiotic resistance markers.
Why it matters:
- Removing unnecessary sequences reduces molecular weight, improving transfection efficiency in mammalian cells.
- CorePrep DNA avoids features regulatory agencies often flag, such as antibiotic resistance genes or bacterial elements.
- Deliver genes that can’t be propagated in E. coli — no cloning bottlenecks.
- CorePrep DNA can serve as a clean, high-performance template for in vitro transcription and translation systems.
CorePrep delivers exactly what your system needs — and nothing it doesn’t.

Compliance and Biosecurity
We comply with all relevant U.S. federal policies related to biosecurity, synthetic DNA screening, and export control. Every order is screened using Aclid, a state-of-the-art platform for identifying sequences that may pose a potential biological hazard.
As part of our commitment to responsible innovation, we also practice customer due diligence. If a sequence or order raises concerns, we may request additional information about:
- intended use of the DNA
- nature of the project
- identity of the client
These measures help ensure that our technology is used safely and in alignment with public health and security standards.
Backed by Research. Built with Purpose.
GenoCAD’s technologies are grounded in over a decade of peer-reviewed research and federally funded innovation.
Supported by Major U.S. Funding Agencies
Our work has been funded by the National Science Foundation and the National Institutes of Health:
- NIH R01GM147816: Development
of a technology to certify engineered DNA molecules - NSF 1241328: INSPIRE: Modeling and optimization of DNA manufacturing processes
- NSF 0850100: GenoCAD: A Computer Assisted Design Environment for Synthetic Biology
Published in High-Impact Journals
Our innovations have been validated through publications cited thousands of times in the scientific literature.
- Writing DNA with GenoCAD (2009) Nucleic Acids Research
https://doi.org/10.1093/nar/gkp361 - GenoLIB: a database of biological parts derived from a library of common plasmid features (2015) Nucleic Acids Research
https://doi.org/10.1093/nar/gkv272 - Opportunities to apply manufacturing systems analysis techniques in genetic manufacturing systems (2017) Manufacturing
letters
https://doi.org/10.1016/j.mfglet.2017.06.003 - Securing the Exchange of Synthetic Genetic Constructs Using Digital Signatures (2020) ACS Synthetic Biology
https://doi.org/10.1021/acssynbio.0c00401 - Sequencing strategies to ensure accurate plasmid assembly (2024) ACS
Synthetic Biology
https://doi.org/10.1021/acssynbio.4c00539